Tumours are complex systems with dynamic interactions between tumour cells, non-tumour
cells, and extracellular components that comprise the tumour microenvironment (TME). The …

The tetraspanins (TSPANs) are a family of four-transmembrane proteins with 33 members in
mammals. They are variably expressed on the cell surface, various intracellular organelles …

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we
identified a chromosome 3q amplicon that serves as a platform for secretory regulation in …

Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …

Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of
various respiratory diseases. Effective monitoring of lung injury is crucial for the optimal …

Background: MicroRNAs (miRNAs) play a regulatory role in various human cancers. The
roles of hsa-miR-15a-5p, hsa-miR-99b-5p, and hsa-miR-181a-5p have not been fully …

Recent research emphasised the indispensable role of histone lactylation in the activation of
hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell …

Increasing evidence suggests that tissue inhibitor of metalloproteinase 1 (TIMP1) played a
pivotal role in immune regulation. Our study focused on examining the expression and …

Background Colorectal cancer (CRC) is the second leading cause of cancer-related deaths
in the world. This study aimed to develop a urea cycle (UC)-related gene signature that …

Background Tumor-associated fibrosis modifies the tumor microenvironment (TME), hinders
the infiltration and activity of cytotoxic immune cells, and is a critical pathological process …