Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Dysregulated pH is a common characteristic of cancer cells, as they have an increased
intracellular pH (pHi) and a decreased extracellular pH (pHe) compared with normal cells …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates
tumor cell invasion by affecting immune cell function, clonal cell evolution, and drug …

Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated
compartments where cells sense environmental cues. The physical mechanisms and …

Highlights•FAK undergoes conformational activation and dimerization.•FAK activation can
occur at adhesions, on endosomes, and in the nucleus.•FAK localizes to adherens junctions …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …