One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Accurate chromosome segregation relies on dynamic interactions between microtubules
(MTs) and the NDC80 complex, a major kinetochore MT-binding component …

As a mechanical system, the kinetochore can be viewed as a set of interacting springs,
clutches and motors; the problem of kinetochore mechanism is now one of understanding …

We introduce a Stochastic Reaction-Diffusion-Dynamics Model (SRDDM) for simulations of
cellular mechanochemical processes with high spatial and temporal resolution. The SRDDM …

Proper location of the mitotic spindle is critical for chromosome segregation and the
selection of the cell division plane. However, how mitotic spindles sense cell size and shape …

In the mitotic spindle microtubules attach to kinetochores via catch bonds during metaphase,
and microtubule depolymerization forces give rise to stochastic chromosome oscillations …

Chromosome segregation during mitosis is mediated by spindle microtubules that attach to
chromosomal kinetochores with strong yet labile links. The exact molecular composition of …

In this paper we construct and analyze a mathematical model for kinetochore (Kt) motors
operating at the chromosome/microtubule interface. Motor dynamics are modeled using a …

This chapter reviews experimental and theoretical studies of force generation by the
polymerization and depolymerization of tubulin polymers (ie, microtubules). Microtubules …

遗传学是生物学科的核心课程, 在生物学的教学与研究中具有十分重要的作用,
而遗传学的知识原理与物理学的知识原理具有一定的相似性. 由于遗传学教学内容较为抽象 …