Acinetobacter baumannii Antibiotic Resistance Mechanisms
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to
public health by causing severe and invasive (mostly nosocomial) infections linked with high …
public health by causing severe and invasive (mostly nosocomial) infections linked with high …
Arsenic in medicine: past, present and future
Arsenicals are one of the oldest treatments for a variety of human disorders. Although
infamous for its toxicity, arsenic is paradoxically a therapeutic agent that has been used …
infamous for its toxicity, arsenic is paradoxically a therapeutic agent that has been used …
Molecular dynamics simulation of protein and protein–ligand complexes
R Shukla, T Tripathi - Computer-aided drug design, 2020 - Springer
Biomacromolecules, including proteins and their complexes, adopt multiple conformations
that are linked to their biological functions. Though some of the structural heterogeneity can …
that are linked to their biological functions. Though some of the structural heterogeneity can …
Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms
Biofilms formed by pathogenic bacteria present a persistent risk to human health. While the
eradication of matured biofilms remains a formidable challenge, delaying or preventing their …
eradication of matured biofilms remains a formidable challenge, delaying or preventing their …
Structural analysis of biomacromolecules using circular dichroism spectroscopy
X Zhao, Y Wang, D Zhao - … Methods to Study Biomolecular Structure and …, 2023 - Elsevier
The chirality of biomacromolecules renders circular dichroism (CD) detection a method to
measure their multiscale structures. This chapter reviews the applications of CD …
measure their multiscale structures. This chapter reviews the applications of CD …
Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
glyoxylate shunt. In the present investigation, we studied the conformational flexibility of …
Advances in engineering UDP-sugar supply for recombinant biosynthesis of glycosides in microbes
Y Feng, M Yao, Y Wang, M Ding, J Zha, W Xiao… - Biotechnology …, 2020 - Elsevier
Plant glycosides are of great interest for industries. Glycosylation of plant secondary
metabolites can greatly improve their solubility, biological activity, or stability. This allows …
metabolites can greatly improve their solubility, biological activity, or stability. This allows …
Identification of potential inhibitors of Fasciola gigantica thioredoxin1: computational screening, molecular dynamics simulation, and binding free energy studies
Fasciola gigantica is the causative organism of fascioliasis and is responsible for major
economic losses in livestock production globally. F. gigantica thioredoxin1 (FgTrx1) is an …
economic losses in livestock production globally. F. gigantica thioredoxin1 (FgTrx1) is an …
In silico study on the inhibition of UDP-N-acetylglucosamine 1-carboxy vinyl transferase from Salmonella typhimurium by the lipopeptide produced from Bacillus …
DA Yaraguppi, ZK Bagewadi, SH Deshpande… - International Journal of …, 2022 - Springer
The protein UDP-N-acetylglucosamine 1-carboxy vinyl transferase (MurA) present in
Salmonella typhimurium is responsible for the cell wall synthesis process. MurA is directly …
Salmonella typhimurium is responsible for the cell wall synthesis process. MurA is directly …
Structural insights into natural compounds as inhibitors of Fasciola gigantica thioredoxin glutathione reductase
Fascioliasis is caused by the helminth parasites of genus Fasciola. Thioredoxin glutathione
reductase (TGR) is an important enzyme in parasitic helminths and plays an indispensable …
reductase (TGR) is an important enzyme in parasitic helminths and plays an indispensable …