The hallmarks of cancer metabolism: Still emerging

NN Pavlova, J Zhu, CB Thompson - Cell metabolism, 2022 - cell.com
Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management

S Pati, W Irfan, A Jameel, S Ahmed, RK Shahid - Cancers, 2023 - mdpi.com
Simple Summary Obesity has been linked to several common cancers including breast,
colorectal, esophageal, kidney, gallbladder, uterine, pancreatic, and liver cancer. Obesity …

Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN

E Morgan, M Arnold, A Gini, V Lorenzoni, CJ Cabasag… - Gut, 2023 - gut.bmj.com
Objective Colorectal cancer (CRC) is the third most common cancer worldwide. The
geographical and temporal burden of this cancer provides insights into risk factor …

[HTML][HTML] The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019

KB Tran, JJ Lang, K Compton, R Xu, AR Acheson… - The Lancet, 2022 - thelancet.com
Background Understanding the magnitude of cancer burden attributable to potentially
modifiable risk factors is crucial for development of effective prevention and mitigation …

Anti-obesity drug discovery: advances and challenges

TD Müller, M Blüher, MH Tschöp… - Nature Reviews Drug …, 2022 - nature.com
Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

Planning for tomorrow: global cancer incidence and the role of prevention 2020–2070

I Soerjomataram, F Bray - Nature reviews Clinical oncology, 2021 - nature.com
Cancer is currently the first or second most common contributor to premature mortality in
most countries of the world. The global number of patients with cancer is expected to rise …

[HTML][HTML] Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019

HH Kyu, A Vongpradith, SB Sirota… - The Lancet Infectious …, 2022 - thelancet.com
Background The global burden of lower respiratory infections (LRIs) and corresponding risk
factors in children older than 5 years and adults has not been studied as comprehensively …

Global burden of 5 major types of gastrointestinal cancer

M Arnold, CC Abnet, RE Neale, J Vignat… - Gastroenterology, 2020 - Elsevier
Background & Aims There were an estimated 4.8 million new cases of gastrointestinal (GI)
cancers and 3.4 million related deaths, worldwide, in 2018. GI cancers account for 26% of …

Obesity and cancer risk: Emerging biological mechanisms and perspectives

KI Avgerinos, N Spyrou, CS Mantzoros, M Dalamaga - Metabolism, 2019 - Elsevier
Continuously rising trends in obesity-related malignancies render this disease spectrum a
public health priority. Worldwide, the burden of cancer attributable to obesity, expressed as …

[HTML][HTML] BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

T Zimmermann, L Thomas, T Baader-Pagler… - Molecular …, 2022 - Elsevier
Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …