The use of genomics is firmly established in clinical practice, resulting in innovations across a wide range of disciplines such as genetic screening, rare disease diagnosis and …
Y Chu, E Dai, Y Li, G Han, G Pei, DR Ingram… - Nature medicine, 2023 - nature.com
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
JX Caushi, J Zhang, Z Ji, A Vaghasia, B Zhang… - Nature, 2021 - nature.com
Abstract PD-1 blockade unleashes CD8 T cells, including those specific for mutation- associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit …
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the contributions of specific tissue environments to TRM cell differentiation and homeostasis are …
TH Ambrosi, O Marecic, A McArdle, R Sinha, GS Gulati… - Nature, 2021 - nature.com
Loss of skeletal integrity during ageing and disease is associated with an imbalance in the opposing actions of osteoblasts and osteoclasts. Here we show that intrinsic ageing of …
Myocardial infarction is a leading cause of death worldwide. Although advances have been made in acute treatment, an incomplete understanding of remodelling processes has limited …
The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the …
Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …
How cell-to-cell copy number alterations that underpin genomic instability in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer, remains …