Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Microglia and central nervous system–associated macrophages—from origin to disease modulation
The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …
immune cells. These are highly specialized macrophages found either in the parenchyma …
[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …
development, homeostasis, and disease. However, until now, the ability to model …
[HTML][HTML] Emerging microglia biology defines novel therapeutic approaches for Alzheimer's disease
JW Lewcock, K Schlepckow, G Di Paolo, S Tahirovic… - Neuron, 2020 - cell.com
Alzheimer's disease (AD) is currently untreatable, and therapeutic strategies aimed to slow
cognitive decline have not yet been successful. Many of these approaches have targeted the …
cognitive decline have not yet been successful. Many of these approaches have targeted the …
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
NM Dräger, SM Sattler, CTL Huang, OM Teter… - Nature …, 2022 - nature.com
Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …
systematic understanding of the underlying mechanisms. Here, we present a screening …
Microglia-containing human brain organoids for the study of brain development and pathology
W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …
brain development and homeostasis. Increasing evidence has implicated microglia …
Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in
animal models cannot accurately model human microglia due to notable transcriptomic and …
animal models cannot accurately model human microglia due to notable transcriptomic and …
[HTML][HTML] Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease
Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …
syndrome (DS) is the most common genetic developmental disorder and risk factor for AD …
The emerging tale of microglia in psychiatric disorders
As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …
response and play an increasingly important role in maintaining homeostatic brain functions …
Efficient strategies for microglia replacement in the central nervous system
Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of
gene-deficient microglia contribute to the development and progression of multiple CNS …
gene-deficient microglia contribute to the development and progression of multiple CNS …