Neisseria gonorrhoeae co-opts C4b-binding protein to enhance complement-independent survival from neutrophils

LM Werner, A Alcott, F Mohlin, JC Ray… - PLoS …, 2023 - journals.plos.org
Neisseria gonorrhoeae (Gc) is a human-specific pathogen that causes the sexually
transmitted infection gonorrhea. Gc survives in neutrophil-rich gonorrheal secretions, and …

Addressing Sexually Transmitted Infections Due to Neisseria gonorrhoeae in the Present and Future

J Colón Pérez, RA Villarino Fernández… - Microorganisms, 2024 - mdpi.com
It was in the 1800s when the first public publications about the infection and treatment of
gonorrhoea were released. However, the first prevention programmes were only published …

Development and implementation of a Type IC CRISPR-based programmable repression system for Neisseria gonorrhoeae

WE Geslewitz, A Cardenas, X Zhou, Y Zhang, AK Criss… - MBio, 2024 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeats (CRISPR) are prokaryotic
adaptive immune systems regularly utilized as DNA-editing tools. While Neisseria …

Phagocytosis via complement receptor 3 enables microbes to evade killing by neutrophils

A Smirnov, KP Daily, MC Gray… - Journal of Leukocyte …, 2023 - academic.oup.com
Abstract CR3 (CD11b/CD18; αmβ2 integrin) is a conserved phagocytic receptor. The active
conformation of CR3 binds the iC3b fragment of complement C3 as well as many host and …

Phase variable colony variants are conserved across Gardnerella spp. and exhibit different virulence-associated phenotypes

EM Garcia, AK Klimowicz, L Edupuganti, MA Topf… - Msphere, 2024 - journals.asm.org
The Gardnerella genus, comprising at least 13 species, is associated with the polymicrobial
disorder bacterial vaginosis (BV). However, the details of BV pathogenesis are poorly …

Tackling immunosuppression by Neisseria gonorrhoeae to facilitate vaccine design

RA Jones, F Ramirez-Bencomo, G Whiting… - PLoS …, 2024 - journals.plos.org
Gonorrhoea, caused by Neisseria gonorrhoeae, is a common sexually transmitted infection.
Increasing multi-drug resistance and the impact of asymptomatic infections on sexual and …

Human neutrophil‐like cells demonstrate antimicrobial responses to the chronic cyst form of Toxoplasma gondii

KV Bergersen, AD Ramirez, B Kavvathas… - Parasite …, 2023 - Wiley Online Library
The protozoan parasite Toxoplasma gondii infects approximately 2.5 billion people
worldwide. Infection induces a rapid dissemination of parasites throughout the body …

Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance

BL Shaskolskiy, ID Kandinov, DA Gryadunov… - Molecular Biology, 2024 - Springer
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials,
more than 80 million cases of the disease are reported annually worldwide. The gonorrhea …

Neisseria gonorrhoeae scavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation

AJ Cardenas, KS Thomas, MW Broden, NJ Ferraro… - Mbio, 2024 - Am Soc Microbiol
Gonorrhea, caused by the bacterium Neisseria gonorrhoeae (Gc), is characterized by
neutrophilic influx to infection sites. Gc has developed mechanisms to resist killing by …

Neisseria gonorrhoeae

L Qian, GG McSheffrey, SD Gray-Owen… - Molecular Medical …, 2024 - Elsevier
Gonorrhea has been with man since antiquity, being mentioned in the Book of Leviticus of
the Bible and in ancient Chinese writings. Hippocrates, who referred to gonorrhea as …