Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

In recent years, breakthroughs have been made in tumor immunotherapy. However, tumor
immunotherapy, particularly anti-PD-1/PD-L1 immune checkpoint inhibitors, is effective in …

Tissue localization is a critical determinant of T cell immunity. CD8+ T cells are contact-
dependent killers, which requires them to physically be within the tissue of interest to kill …

Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in
the tumor microenvironment, leading to immunosuppressive features. Here, we employed …

Despite advances in treatment, lung cancer survival rates remain low. A better
understanding of the cellular heterogeneity and interplay of cancer-associated fibroblasts …

Only in recent years have we begun to appreciate the involvement of fibroblasts in intestinal
development, tissue homeostasis, and disease. These insights followed the advent of single …

Fibroblasts are the major cell population of connective tissue, including the skin dermis, and
are best known for their function in depositing and remodelling the extracellular matrix …

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading
cause of cancer-related death. Hallmarks include desmoplasia with variable extracellular …

Although cancer-associated fibroblast (CAF) heterogeneity is well-established, the impact of
chemotherapy on CAF populations remains poorly understood. Here we address this …