Protein misfolding, aggregation and deposition are common disease mechanisms in many
neurodegenerative diseases including Parkinson's disease (PD). Accumulation of damaged …

1. Introduction 22. What is the significance of the shared structural properties of disease-
associated protein fibrils? 32.1 Mechanism of amyloid fibril formation in vitro 62.1. 1 In vitro …

Most of the mammalian genome is transcribed,,. This generates a vast repertoire of
transcripts that includes protein-coding messenger RNAs, long non-coding RNAs (lncRNAs) …

Amyloid-beta (Abeta) peptide is the original causative factor of Alzheimer's disease (AD)
according to the amyloid cascade hypothesis. The ubiquitin–proteasome system (UPS), the …

Accumulating studies have revealed that the human genome encodes tens of thousands of
long non-coding RNAs (lncRNAs), which participate in multiple biological networks …

Synuclein aggregation in neuronal cells is the primary underlying cause of
synucleinopathies. Changes in gene expression patterns, structural modifications, and …

DNA methylation occurs predominantly at cytosines that precede guanines in dinucleotide
CpG sites; it is one of the most important mechanisms for epigenetic DNA regulation during …

Parkinson disease (PD) is the second most common neurodegenerative disease after
Alzheimer disease. Although PD has a relatively narrow clinical phenotype, it has become …

Antisense (AS) transcripts are RNA molecules that are transcribed from the opposite strand
to sense (S) genes forming S/AS pairs. The most prominent configuration is when a lncRNA …

Growing evidence shows a close association of transposable elements (TE) with non-coding
RNAs (ncRNA), and a significant number of small ncRNAs originate from TEs. Further …