Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity
Cytotoxic lymphocytes are critical in our immune defence against cancer and infection.
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells …
Death receptors as targets in cancer
Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …
High expression of trimethylated histone H3 lysine 4 is associated with poor prognosis in hepatocellular carcinoma
Tumor-associated epigenetic alterations including DNA methylation and histone
modifications are important determinants in the initiation and progression of hepatocellular …
modifications are important determinants in the initiation and progression of hepatocellular …
Tumor resistance mechanisms and their consequences on γδ T cell activation
D Wesch, D Kabelitz, HH Oberg - Immunological reviews, 2020 - Wiley Online Library
Human γδ T lymphocytes are predominated by two major subsets, defined by the variable
domain of the δ chain. Both, Vδ1 and Vδ2 T cells infiltrate in tumors and have been …
domain of the δ chain. Both, Vδ1 and Vδ2 T cells infiltrate in tumors and have been …
[PDF][PDF] Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes …
R Urtasun, MU Latasa, MI Demartis, S Balzani… - …, 2011 - Wiley Online Library
The identification of molecular mechanisms involved in the maintenance of the transformed
phenotype of hepatocellular carcinoma (HCC) cells is essential for the elucidation of …
phenotype of hepatocellular carcinoma (HCC) cells is essential for the elucidation of …
The role of TRAIL/DRs in the modulation of immune cells and responses
Expression of TRAIL (tumor necrosis factor–related apoptosis–inducing ligand) by immune
cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly …
cells can lead to the induction of apoptosis in tumor cells. However, it becomes increasingly …
Apoptosis-modulating drugs for improved cancer therapy
M Ocker, M Höpfner - European surgical research, 2012 - karger.com
Resistance to cell death induction has been recognized as a hallmark of cancer. Increasing
understanding of the underlying molecular events regulating different cell death …
understanding of the underlying molecular events regulating different cell death …
Inflammation and liver tumorigenesis
B Sun, M Karin - Frontiers of medicine, 2013 - Springer
Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis
is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation …
is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation …
Revisiting the role of TRAIL/TRAIL-R in cancer biology and therapy
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, can
induce apoptosis in cancer cells, sparing normal cells when bound to its associated death …
induce apoptosis in cancer cells, sparing normal cells when bound to its associated death …
Targeting cyclin dependent kinase 5 in hepatocellular carcinoma–A novel therapeutic approach
SM Ehrlich, J Liebl, MA Ardelt, T Lehr, EN De Toni… - Journal of …, 2015 - Elsevier
Background & Aims For a long time cyclin dependent kinase 5 (Cdk5) was thought to be
exclusively important in neuronal cells. However, increasing evidence recently suggests a …
exclusively important in neuronal cells. However, increasing evidence recently suggests a …