[HTML][HTML] Molecular mechanism of TRP channels

J Zheng - Comprehensive Physiology, 2013 - ncbi.nlm.nih.gov
Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

Chemosensory signal transduction in Caenorhabditis elegans

DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

The complex story of plant cyclic nucleotide-gated channels

E Jarratt-Barnham, L Wang, Y Ning… - International Journal of …, 2021 - mdpi.com
Plant cyclic nucleotide-gated channels (CNGCs) are tetrameric cation channels which may
be activated by the cyclic nucleotides (cNMPs) adenosine 3′, 5′-cyclic monophosphate …

Why are rods more sensitive than cones?

NT Ingram, AP Sampath, GL Fain - The Journal of physiology, 2016 - Wiley Online Library
One hundred and fifty years ago Max Schultze first proposed the duplex theory of vision, that
vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for dim …

Structure of the human cone photoreceptor cyclic nucleotide-gated channel

X Zheng, Z Hu, H Li, J Yang - Nature structural & molecular biology, 2022 - nature.com
Cyclic nucleotide-gated (CNG) channels transduce light-induced chemical signals into
electrical signals in retinal cone and rod photoreceptors. Structures of native CNG channels …

Structural insights into the mechanisms of CNBD channel function

ZM James, WN Zagotta - Journal of General Physiology, 2018 - rupress.org
Cyclic nucleotide-binding domain (CNBD) channels are a family of ion channels in the
voltage-gated K+ channel superfamily that play crucial roles in many physiological …

[HTML][HTML] Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel

J Xue, Y Han, W Zeng, Y Jiang - Neuron, 2022 - cell.com
Mammalian cyclic nucleotide-gated (CNG) channels are nonselective cation channels
activated by cGMP or cAMP and play essential roles in the signal transduction of the visual …

Speed, sensitivity, and stability of the light response in rod and cone photoreceptors: facts and models

JI Korenbrot - Progress in retinal and eye research, 2012 - Elsevier
The light responses of rod and cone photoreceptors in the vertebrate retina are
quantitatively different, yet extremely stable and reproducible because of the extraordinary …

Retinal cyclic nucleotide-gated channels: from pathophysiology to therapy

S Michalakis, E Becirovic, M Biel - International Journal of Molecular …, 2018 - mdpi.com
The first step in vision is the absorption of photons by the photopigments in cone and rod
photoreceptors. After initial amplification within the phototransduction cascade the signal is …

The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods

DCA Barret, GFX Schertler, UB Kaupp… - Nature Structural & …, 2022 - nature.com
In rod photoreceptors of the retina, the cyclic nucleotide-gated (CNG) channel is composed
of three CNGA and one CNGB subunits, and it closes in response to light activation to …