The OrganiX microfluidic system to recreate the complex tumour microenvironment | Nature
Reviews Immunology Skip to main content Thank you for visiting nature.com. You are using a …

Colorectal cancer (CRC) is a leading cause of death worldwide. Improved preclinical tumor
models are needed to make treatment screening clinically relevant and address disease …

Glioblastoma (GBM) is the most common primary malignant brain cancer in adults with a
dismal prognosis. Temozolomide (TMZ) is the first‐in‐line chemotherapeutic; however …

Metastatic renal cell carcinoma (RCC) remains an incurable disease for most patients
highlighting an urgent need for new treatments. However, the preclinical investigation of …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies nowadays.
The available chemo-and immunotherapies are often ineffective in treating PDAC due to its …

Successful immunotherapy relies on both intratumoral and systemic immunity, which is yet to
be achieved for most patients with cancer. Here, we identify P4HA1, encoding prolyl 4 …

The limited recapitulation of critical cancer features in two‐dimensional (2D) cultures causes
poor translatability of preclinical results from in vitro assays to in vivo tumor models. This …

Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play
an important role in controlling transcription by altering the chromatin structure. Aberrant …

Microphysiological systems (MPS) are gaining broader application in the pharmaceutical
industry but have primarily been leveraged in early discovery toxicology and pharmacology …

近年来, 晚期非小细胞肺癌(NSCLC) 的治疗领域取得了显著进展, 特别是以程序性死亡分子-1
(PD-1) 及其配体(PD-L1) 抑制剂为代表的免疫治疗, 为这类患者提供了新的治疗选择. 然而 …