Cysteine side chains can exist in distinct oxidation states depending on the pH and redox
potential of the environment, and cysteine oxidation plays important yet complex regulatory …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Nuclear receptor related 1 (Nurr1) is a neuroprotective transcription factor and an emerging
target in neurodegenerative diseases. Despite strong evidence for a role in Parkinson's and …

The orphan nuclear receptor Nurr1 is critical for the development, maintenance and
protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 …

Nuclear receptor related 1 (Nurr1) is a transcription factor with neuroprotective and
antineuroinflammatory properties. Observations from genetic studies and human patients …

Astrocytes protect neurons by modulating neuronal function and survival. Astrocytes support
neurons in several ways. They provide energy through the astrocyte-neuron lactate shuttle …

Nurr1/NR4A2 is an orphan nuclear receptor transcription factor implicated as a drug target
for neurological disorders including Alzheimer's and Parkinson's diseases. Previous studies …

Dopamine is an important neurotransmitter that plays a critical role in motivational salience
and motor coordination. However, dysregulated dopamine metabolism can result in the …

Immune checkpoint blockade (ICB) therapies, which block inhibitory receptors on T cells,
can be efficacious in reinvigorating dysfunctional T cell responses. However, most cancers …