DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …

DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Chromothripsis is a catastrophic mutational process that promotes tumorigenesis and
causes congenital disease,,–. Chromothripsis originates from aberrations of nuclei called …

The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of
demethylating DNA and activating genes. Further experiments, however, unearthed an …

Ten-eleven translocation 1–3 (Tet1–3) proteins have recently been discovered in
mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …

Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …

DNA methylation at the 5-position of cytosines (5mC) represents an important epigenetic
modification involved in tissue differentiation and is frequently altered in cancer. Recent …

Transposable elements (TEs) account for at least 50% of the human genome. They
constitute essential motors of evolution through their ability to modify genomic architecture …

The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …