The penetration of polar or badly soluble compounds through a cell membrane into live cells
requires mechanical support or chemical helpers. Cell‐penetrating peptides (CPPs) are very …

The concept of biased agonism has recently come to the fore with the realization that seven-
transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) …

Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

GPER possesses structural and functional characteristics shared by members of the G-
protein-coupled receptor (GPCR) superfamily, the largest class of plasma membrane …

Prostanoids are potent oxygenated lipid molecules that contribute to a wide variety of
physiological responses and pathological processes. They are generated by the metabolism …

GPER is a G s-coupled seven-transmembrane receptor that has been linked to specific
estrogen binding and signaling activities that are manifested by plasma membrane …

G protein-coupled receptors (GPCRs) are organised within the cell membrane into highly
ordered macromolecular complexes along with other receptors and signalling proteins …

Background Chronic pain and stress-related psychopathologies, such as depression and
anxiety-associated abnormalities, are mutually reinforcing; however, the neuronal circuits …

The melanocortin system is composed by the agonists adrenocorticotropic hormone and α, β
and γ-melanocyte-stimulating hormone, and two naturally occurring antagonists, agouti and …

G protein-coupled receptors (GPCRs) comprise the largest family of membrane receptors
that control many cellular processes and consequently often serve as drug targets. These …