Architecture of human Rag GTPase heterodimers and their complex with mTORC1
M Anandapadamanaban, GR Masson, O Perisic… - Science, 2019 - science.org
The Rag guanosine triphosphatases (GTPases) recruit the master kinase mTORC1 to
lysosomes to regulate cell growth and proliferation in response to amino acid availability …
lysosomes to regulate cell growth and proliferation in response to amino acid availability …
Structural basis of cytokine-mediated activation of ALK family receptors
S De Munck, M Provost, M Kurikawa, I Omori… - Nature, 2021 - nature.com
Anaplastic lymphoma kinase (ALK) and the related leukocyte tyrosine kinase (LTK) are
recently deorphanized receptor tyrosine kinases. Together with their activating cytokines …
recently deorphanized receptor tyrosine kinases. Together with their activating cytokines …
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions.
Studies of motif-mediated interactions therefore provide insight into virus-host …
Studies of motif-mediated interactions therefore provide insight into virus-host …
Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH
A Stsiapanava, C Xu, S Nishio, L Han… - Nature Structural & …, 2022 - nature.com
Abstract Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against
gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin …
gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin …
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
Attachment of ubiquitin (Ub) to proteins is one of the most abundant and versatile of all
posttranslational modifications and affects outcomes in essentially all physiological …
posttranslational modifications and affects outcomes in essentially all physiological …
Crystal structures and nuclear magnetic resonance studies of the apo form of the c-MYC: MAX bHLHZip complex reveal a helical basic region in the absence of DNA
The c-MYC transcription factor is a master regulator of cell growth and proliferation and is an
established target for cancer therapy. This basic helix–loop–helix Zip protein forms a …
established target for cancer therapy. This basic helix–loop–helix Zip protein forms a …
A molecular basis for the T cell response in HLA-DQ2. 2 mediated celiac disease
YT Ting, S Dahal-Koirala, HSK Kim… - Proceedings of the …, 2020 - National Acad Sciences
The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2. 5 and
HLA-DQ2. 2, are implicated in the pathogenesis of celiac disease (CeD) by presenting …
HLA-DQ2. 2, are implicated in the pathogenesis of celiac disease (CeD) by presenting …
[HTML][HTML] Protein crystallization screens developed at the MRC Laboratory of Molecular Biology
F Gorrec - Drug Discovery Today, 2016 - Elsevier
Highlights•We present three types of initial screens and an optimization screen for protein
crystallization.•Published conditions were selected to formulate the LMB sparse matrix.•Pi …
crystallization.•Published conditions were selected to formulate the LMB sparse matrix.•Pi …
Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase
D Fernández‐Justel, Í Marcos‐Alcalde… - Protein …, 2022 - Wiley Online Library
IMP dehydrogenase (IMPDH) is an essential enzyme that catalyzes the rate‐limiting step in
the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain …
the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain …
Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint
Glycoproteins traversing the eukaryotic secretory pathway begin life in the endoplasmic
reticulum (ER), where their folding is surveyed by the 170-kDa UDP-glucose: glycoprotein …
reticulum (ER), where their folding is surveyed by the 170-kDa UDP-glucose: glycoprotein …