[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
B Rehermann - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …
made in our understanding of its life cycle and interaction with the host immune system …
SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses
B Agerer, M Koblischke, V Gudipati… - Science …, 2021 - science.org
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus
control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell …
control. Here, we identified nonsynonymous mutations in MHC-I-restricted CD8+ T cell …
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …
and effectively evaded immune responses, its viral fitness in cell and animal models was …
Memory-like HCV-specific CD8+ T cells retain a molecular scar after cure of chronic HCV infection
N Hensel, Z Gu, Sagar, D Wieland, K Jechow… - Nature …, 2021 - nature.com
In chronic hepatitis C virus (HCV) infection, exhausted HCV-specific CD8+ T cells comprise
memory-like and terminally exhausted subsets. However, little is known about the molecular …
memory-like and terminally exhausted subsets. However, little is known about the molecular …
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
immunity to chronic viral infection. Defining novel markers of exhaustion is important both for …
Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans
T cell exhaustion is an induced state of dysfunction that arises in response to chronic
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
infection and cancer. Exhausted CD8+ T cells acquire a distinct epigenetic state, but it is not …
Randomized trial of a vaccine regimen to prevent chronic HCV infection
K Page, MT Melia, RT Veenhuis, M Winter… - … England Journal of …, 2021 - Mass Medical Soc
Background A safe and effective vaccine to prevent chronic hepatitis C virus (HCV) infection
is a critical component of efforts to eliminate the disease. Methods In this phase 1–2 …
is a critical component of efforts to eliminate the disease. Methods In this phase 1–2 …
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
T cell exhaustion is associated with failure to clear chronic infections and malignant cells.
Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to …
Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to …
TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation
D Wieland, J Kemming, A Schuch, F Emmerich… - Nature …, 2017 - nature.com
Differentiation and fate of virus-specific CD8+ T cells after cessation of chronic antigen
stimulation is unclear. Here we show that a TCF1+ CD127+ PD1+ hepatitis C virus (HCV) …
stimulation is unclear. Here we show that a TCF1+ CD127+ PD1+ hepatitis C virus (HCV) …