Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that regulate the
turnover of extracellular matrix (ECM) components. Gross and La Piere discovered MMPs in …

Matrix metalloproteinases (MMPs), a group of zinc-dependent endopeptidases involved in
the degradation of the extracellular matrix, play an important role in tissue remodeling …

Recent epidemiological studies have revealed a significant association between
periodontitis and oral squamous cell carcinoma (OSCC). Furthermore, matrix …

Cancer is one of the most complex and systemic diseases affecting the health of mankind,
causing major deaths with a significant increase. This pathology is caused by several risk …

Tmprss2 encodes an androgen-regulated type II transmembrane serine protease (TTSP)
expressed highly in normal prostate epithelium and has been implicated in prostate …

[Frontiers in Bioscience 11, 479-491, January 1, 2006] 479 Matrix metalloproteinases: roles in
cancer and metastasis Barbara Fin Page 1 [Frontiers in Bioscience 11, 479-491, January 1 …

TMPRSS2 is a type II transmembrane-bound serine protease that has gained interest owing
to its highly localized expression in the prostate and its overexpression in neoplastic …

Context Prostate-specific membrane antigen (PSMA) is a promising, novel theranostic target
in advanced prostate cancer (PCa). Multiple PSMA-targeted therapies are currently in …

The transmembrane serine protease matriptase is a key regulator of both barrier-disruptive
and protective epithelial cell–cell interactions. Elevated matriptase is a consistent feature of …