The complexity of the intrarenal renin-angiotensin (Ang) system (RAS) continues to reveal
itself as evidence accumulates demonstrating its robust independent regulation in the …

Angiotensin II content in the kidney is much higher than in the plasma, and it increases more
in kidney diseases through an uncertain mechanism. Because the kidney abundantly …

The purpose of this review is to examine sex differences in response to stimulation and
inhibition of the renin-angiotensin system (RAS). The RAS plays a prominent role in the …

Numerous epidemiological studies suggest an inverse relationship between low birth weight
(LBW) and hypertension, an observation now supported by numerous animal studies. The …

purpose. To investigate the involvement of the renin-angiotensin system (RAS) and the
nuclear factor (NF)-κB pathway with diabetes-induced retinal inflammation. methods. Six …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear
transcription factors that belong to the nuclear receptor superfamily. Three isoforms of PPAR …

Background—The presence of chronic kidney disease is a significant independent risk
factor for poor prognosis in patients with chronic heart failure. However, the mechanisms …

Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease
and the progression of COVID-19 has been demonstrated. Kidney disease is an …

The renin-angiotensin system (RAS) is a well-studied hormonal cascade controlling fluid
and electrolyte balance and blood pressure through systemic actions. The classical RAS …

Chronic angiotensin (ANG) II infusions into rats lead to augmented intrarenal levels of ANG II
and inflammatory factors, impaired renal function, and progressive hypertension. Residual …