Neurotoxins and their binding areas on voltage-gated sodium channels
M Stevens, S Peigneur, J Tytgat - Frontiers in pharmacology, 2011 - frontiersin.org
Voltage-gated sodium channels (VGSCs) are large transmembrane proteins that conduct
sodium ions across the membrane and by doing so they generate signals of communication …
sodium ions across the membrane and by doing so they generate signals of communication …
Spider-venom peptides as bioinsecticides
Over 10,000 arthropod species are currently considered to be pest organisms. They are
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …
estimated to contribute to the destruction of~ 14% of the world's annual crop production and …
Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads
Voltage-gated sodium (NaV) channels play a central role in the propagation of action
potentials in excitable cells in both humans and insects. Many venomous animals have …
potentials in excitable cells in both humans and insects. Many venomous animals have …
Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli
Disulfide-rich peptides are the dominant component of most animal venoms. These peptides
have received much attention as leads for the development of novel therapeutic agents and …
have received much attention as leads for the development of novel therapeutic agents and …
Use of venom peptides to probe ion channel structure and function
S Dutertre, RJ Lewis - Journal of biological chemistry, 2010 - ASBMB
Venoms of snakes, scorpions, spiders, insects, sea anemones, and cone snails are complex
mixtures of mostly peptides and small proteins that have evolved for prey capture and/or …
mixtures of mostly peptides and small proteins that have evolved for prey capture and/or …
Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration
Peptide toxins with high affinity, divergent pharmacological functions, and isoform-specific
selectivity are powerful tools for investigating the structure-function relationships of voltage …
selectivity are powerful tools for investigating the structure-function relationships of voltage …
Peptide toxins in sea anemones: structural and functional aspects
T Honma, K Shiomi - Marine biotechnology, 2006 - Springer
Sea anemones are a rich source of two classes of peptide toxins, sodium channel toxins and
potassium channel toxins, which have been or will be useful tools for studying the structure …
potassium channel toxins, which have been or will be useful tools for studying the structure …
Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment
SD Dib-Hajj, AM Binshtok, TR Cummins, MF Jarvis… - Brain research …, 2009 - Elsevier
Pain is a major unmet medical need which has been causally linked to changes in sodium
channel expression, modulation, or mutations that alter channel gating properties or current …
channel expression, modulation, or mutations that alter channel gating properties or current …
The insecticidal potential of venom peptides
Pest insect species are a burden to humans as they destroy crops and serve as vectors for a
wide range of diseases including malaria and dengue. Chemical insecticides are currently …
wide range of diseases including malaria and dengue. Chemical insecticides are currently …
Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from tarantulas
CH Yuan, QY He, K Peng, JB Diao, LP Jiang, X Tang… - PloS one, 2008 - journals.plos.org
Background Kuntiz-type toxins (KTTs) have been found in the venom of animals such as
snake, cone snail and sea anemone. The main ancestral function of Kunitz-type proteins …
snake, cone snail and sea anemone. The main ancestral function of Kunitz-type proteins …