Recent developments in the synthesis of hybrid antimalarial drug discovery
In this 21 st century, Malaria remains a global burden and causes massive economic trouble
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
to disease-endemic nations. The control and eradication of malaria is a major challenge that …
Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update
SK Pandey, U Anand, WA Siddiqui… - Advances in …, 2023 - Wiley Online Library
Malaria continued to be a deadly situation for the people of tropical and subtropical
countries. Although there has been a marked reduction in new cases as well as mortality …
countries. Although there has been a marked reduction in new cases as well as mortality …
High prevalence of Pfcrt 76T and Pfmdr1 N86 genotypes in malaria infected patients attending health facilities in East Shewa zone, Oromia Regional State, Ethiopia
Background Plasmodium falciparum resistance to series of anti-malarial drugs is a major
challenge in efforts to control and/or eliminate malaria globally. In 1998, following the …
challenge in efforts to control and/or eliminate malaria globally. In 1998, following the …
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes
All organisms are defined by the makeup of their DNA. Over billions of years, the structure
and information contained in that DNA, often referred to as genetic architecture, have been …
and information contained in that DNA, often referred to as genetic architecture, have been …
Synthesis, anti-plasmodial activities, and mechanistic insights of 4-aminoquinoline-triazolopyrimidine hybrids
S Chowdhary, Shalini, J Mosnier, I Fonta… - ACS Medicinal …, 2022 - ACS Publications
In the search of new antiplasmodial agents, a multitargeted approach was used in the
synthesis of triazolopyrimidine-and 4-aminoquinolines-based hybrids. In vitro antiplasmodial …
synthesis of triazolopyrimidine-and 4-aminoquinolines-based hybrids. In vitro antiplasmodial …
A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in …
The emergence of drug-resistant Plasmodium falciparum parasites in sub-Saharan Africa
will substantially challenge malaria control. Here, we evaluated the frequency of common …
will substantially challenge malaria control. Here, we evaluated the frequency of common …
Whole genome sequencing contributions and challenges in disease reduction focused on malaria
Simple Summary Malaria is one of the most severe life-threatening human vector-borne
diseases worldwide today, leading to high mortality. Children under the age of five and …
diseases worldwide today, leading to high mortality. Children under the age of five and …
Plasmodium falciparum topoisomerases: Emerging targets for anti-malarial therapy
Different metabolic pathways like DNA replication, transcription, and recombination
generate topological constrains in the genome. These topological constraints are resolved …
generate topological constrains in the genome. These topological constraints are resolved …
Updates on traditional methods for combating malaria and emerging Wolbachia-based interventions
The escalating challenge of malaria control necessitates innovative approaches that extend
beyond traditional control strategies. This review explores the incorporation of traditional …
beyond traditional control strategies. This review explores the incorporation of traditional …
The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest …
Intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-
SP) is used to prevent malaria and associated unfavorable maternal and foetal outcomes in …
SP) is used to prevent malaria and associated unfavorable maternal and foetal outcomes in …