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MHC class I molecules are ligands for the killer-cell immunoglobulin-like receptors (KIRs),
which are expressed by natural killer cells and T cells. The interactions between these …

KIR genes have evolved in primates to generate a diverse family of receptors with unique
structures that enable them to recognize MHC-class I molecules with locus and allele …

Killer Ig-like receptor (KIR) genes constitute a multigene family whose genomic diversity is
achieved through differences in gene content and allelic polymorphism. KIR haplotypes …

Beyond midlife, the immune system shows aging features and its defensive capability
becomes impaired, by a process known as immunosenescence that involves many changes …

The fast evolving human KIR gene family encodes variable lymphocyte receptors specific for
polymorphic HLA class I determinants. Nucleotide sequences for 24 representative human …

The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like
receptors has led to a search for their role in human disease. Due to their polymorphism and …

Killer Ig-like receptor (KIR) genes are a multigene family on human chromosome 19. KIR
genes occur in various combinations on different haplotypes. Additionally, KIR genes are …

Inhibitory MHC class I receptors were initially described on natural killer (NK) cells, where
they participate in inducing NK-cell self-tolerance. Inhibitory NK-cell receptors (iNKRs) can …

IFN-γ regulates the immunogenicity of target cells by increasing their expression of HLA
class I molecules. This facilitates the T cell receptor–mediated recognition by CD8+ T cells …