Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

SM Khan, WH Witola - Frontiers in cellular and infection microbiology, 2023 - frontiersin.org
The intracellular protozoan parasite of the genus Cryptosporidium is among the leading
causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is …

Treatment of Cryptosporidium: what we know, gaps, and the way forward

H Sparks, G Nair, A Castellanos-Gonzalez… - … tropical medicine reports, 2015 - Springer
Cryptosporidiosis is increasingly recognized as an important global health concern. While
initially reported in immunocompromised patients such as AIDS patients, cryptosporidiosis …

A comprehensive review of common bacterial, parasitic and viral zoonoses at the human-animal interface in Egypt

YA Helmy, H El-Adawy, EM Abdelwhab - Pathogens, 2017 - mdpi.com
Egypt has a unique geographical location connecting the three old-world continents Africa,
Asia and Europe. It is the country with the highest population density in the Middle East …

Novel treatment strategies and drugs in development for cryptosporidiosis

MA Chavez, AC White Jr - Expert Review of Anti-Infective Therapy, 2018 - Taylor & Francis
Introduction: Cryptosporidium is a protozoan pathogen that can cause diarrheal disease in
healthy and immunosuppressed individuals, worldwide. Recent studies have highlighted the …

New drugs and treatment for cryptosporidiosis

HV Smith, GD Corcoran - Current opinion in infectious diseases, 2004 - journals.lww.com
Cryptosporidiosis remains a significant public health threat. Risk avoidance guidance could
be viewed in the more relative terms of risk management depending on the degree of …

Discovery of Novel Anti-cryptosporidial Activities From Natural Products by in vitro High-Throughput Phenotypic Screening

Z Jin, J Ma, G Zhu, H Zhang - Frontiers in Microbiology, 2019 - frontiersin.org
Cryptosporidium parvum is a globally distributed zoonotic protozoan parasite of both
medical and veterinary importance. Nitazoxanide is the only FDA-approved drug to treat …

[HTML][HTML] Cryptosporidium infection in solid organ transplantation

DF Florescu, U Sandkovsky - World journal of transplantation, 2016 - ncbi.nlm.nih.gov
Diarrhea is a common complication in solid organ transplant (SOT) recipients and may be
attributed to immunosuppressive drugs or infectious organisms such as bacteria, viruses or …

Advances in therapeutic and vaccine targets for Cryptosporidium: Challenges and possible mitigation strategies

SU Rahman, R Mi, S Zhou, H Gong, M Ullah, Y Huang… - Acta Tropica, 2022 - Elsevier
Cryptosporidium is known to be the second most common diarrheal pathogen in children,
causing potentially fatal diarrhea and associated with long-term growth stunting and …

The mechanism of action of praziquantel: six hypotheses

CM Thomas, DJ Timson - Current topics in medicinal chemistry, 2018 - ingentaconnect.com
Despite being one of the most commonly used drugs, the molecular mechanism of action of
the anthelmintic praziquantel remains unknown. There are some unusual features of this …

The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis

S Lee, M Harwood, D Girouard, MJ Meyers… - PLoS …, 2017 - journals.plos.org
Recent reports highlighting the global significance of cryptosporidiosis among children,
have renewed efforts to develop control measures. We have optimized the gnotobiotic piglet …