Molecular and metabolic heterogeneity of astrocytes and microglia
Astrocytes and microglia are central players in a myriad of processes in the healthy and
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell …
Axonal energy metabolism, and the effects in aging and neurodegenerative diseases
Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …
[HTML][HTML] Molecular and spatial signatures of mouse brain aging at single-cell resolution
The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …
characterization of age-related changes in its cellular and molecular architecture, limiting …
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis
Childhood neglect and/or abuse can induce mental health conditions with unknown
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
Intersection of pathological tau and microglia at the synapse
T Vogels, AN Murgoci, T Hromádka - Acta neuropathologica …, 2019 - Springer
Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …
Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …
astrocytes, which provide for homoeostasis and defence of the central nervous system …
[HTML][HTML] The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration
BV Lananna, ES Musiek - Neurobiology of disease, 2020 - Elsevier
A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …
array of diverse biological processes including glial function, metabolism, peripheral …
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
Astrogliosis and activation of microglia are hallmarks of prion diseases in humans and
animals. Both were viewed to be rather independent events in disease pathophysiology …
animals. Both were viewed to be rather independent events in disease pathophysiology …
Heterogeneity of white matter astrocytes in the human brain
M Bugiani, BC Plug, JHK Man, M Breur… - Acta …, 2022 - Springer
Astrocytes regulate central nervous system development, maintain its homeostasis and
orchestrate repair upon injury. Emerging evidence support functional specialization of …
orchestrate repair upon injury. Emerging evidence support functional specialization of …
Physiological and pathological ageing of astrocytes in the human brain
M Verkerke, EM Hol, J Middeldorp - Neurochemical research, 2021 - Springer
Ageing is the greatest risk factor for dementia, although physiological ageing by itself does
not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk …
not lead to cognitive decline. In addition to ageing, APOE ε4 is genetically the strongest risk …