Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among
phospholipids in that its head group can be phosphorylated at multiple free hydroxyls …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Abstract Synthesis of phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2], a signaling
phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI (4) …

It has long been known that phosphoinositides are present in cellular membranes, but only
in the past four decades has our understanding of their importance for proper cell function …

The ability of cells to form cell contacts, adhere to the extracellular matrix, change
morphology, and migrate is essential for development, wound healing, metastasis, cell …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

The Saccharomyces cerevisiae FAB1 gene encodes a 257-kD protein that contains a
cysteine-rich RING-FYVE domain at its NH2-terminus and a kinase domain at its COOH …

1.1. Background Beginning in the early 1980s, cell biologists started realising that some
phospholipids are not just basic constituents of membranes but dynamic informational …