Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is
limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can …

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies;
however, patients can experience cardiotoxic effects and this has limited the use of this …

Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Innate immunity is the first response to protect against pathogens and cellular insults.
Pattern recognition receptors sense pathogen-and damage-associated molecular patterns …

Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …