Synthetic carbohydrate-based vaccines: challenges and opportunities
R Mettu, CY Chen, CY Wu - Journal of Biomedical Science, 2020 - Springer
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been
extremely successful in preventing bacterial infections. The glycan antigens for the …
extremely successful in preventing bacterial infections. The glycan antigens for the …
The changing and dynamic epidemiology of meningococcal disease
The epidemiology of invasive meningococcal disease continues to change rapidly, even in
the three years since the first Meningococcal Exchange Meeting in 2008. Control of disease …
the three years since the first Meningococcal Exchange Meeting in 2008. Control of disease …
Increase in Endemic Neisseria meningitidis Capsular Group W Sequence Type 11 Complex Associated With Severe Invasive Disease in England and Wales
SN Ladhani, K Beebeejaun, J Lucidarme… - Clinical Infectious …, 2015 - academic.oup.com
England and Wales are experiencing a year-on-year increase in meningococcal group W
(MenW) disease since 2009–2010, following rapid expansion of a single endemic …
(MenW) disease since 2009–2010, following rapid expansion of a single endemic …
Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
Abstract Systems vaccinology has defined molecular signatures and mechanisms of
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
immunity to vaccination. However, comparative analysis of immunity to different vaccines is …
Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): lessons from past programs and implications for the future
J Holst, P Oster, R Arnold, M Tatley… - Human vaccines & …, 2013 - Taylor & Francis
The utility of wild-type outer membrane vesicle (wtOMV) vaccines against serogroup B
(MenB) meningococcal disease has been explored since the 1970s. Public health …
(MenB) meningococcal disease has been explored since the 1970s. Public health …
Safety and efficacy of the two doses conjugated protein-based SOBERANA-02 COVID-19 vaccine and of a heterologous three-dose combination with SOBERANA …
ME Toledo-Romaní, M García-Carmenate… - The Lancet Regional …, 2023 - thelancet.com
Background SOBERANA-02 is a COVID-19 conjugate vaccine (recombinant RBD
conjugated to tetanus toxoid). Phases 1/2 clinical trials demonstrated high immunogenicity …
conjugated to tetanus toxoid). Phases 1/2 clinical trials demonstrated high immunogenicity …
Meningococcal vaccines: current status and emerging strategies
PC McCarthy, A Sharyan, L Sheikhi Moghaddam - Vaccines, 2018 - mdpi.com
Neisseria meningitidis causes most cases of bacterial meningitis. Meningococcal meningitis
is a public health burden to both developed and developing countries throughout the world …
is a public health burden to both developed and developing countries throughout the world …
Invasive meningococcal disease in England and Wales: implications for the introduction of new vaccines
SN Ladhani, JS Flood, ME Ramsay, H Campbell… - Vaccine, 2012 - Elsevier
A number of meningococcal vaccines have either been recently licensed or are in late-
phase clinical trials. To inform national vaccination policy, it is important to define the burden …
phase clinical trials. To inform national vaccination policy, it is important to define the burden …
Abundance and co-occurrence of extracellular capsules increase environmental breadth: Implications for the emergence of pathogens
O Rendueles, M Garcia-Garcerà, B Néron… - PLoS …, 2017 - journals.plos.org
Extracellular capsules constitute the outermost layer of many bacteria, are major virulence
factors, and affect antimicrobial therapies. They have been used as epidemiological markers …
factors, and affect antimicrobial therapies. They have been used as epidemiological markers …
Glycoconjugate vaccines: an update
M Vella, D Pace - Expert opinion on biological therapy, 2015 - Taylor & Francis
Introduction: Globally, the three main pathogens causing serious infections are
Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis …
Haemophilus influenzae type b, Streptococcus pneumoniae and Neisseria meningitidis …