The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …

Among the strategies used for enhancement of tumour retention of imaging agents or
anticancer drugs is the rational design of probes that undergo a tumour-specific enzymatic …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Chemical exchange saturation transfer (CEST) is a relatively new contrast mechanism for
MRI. CEST MRI exploits a specific MR frequency (chemical shift) of a molecule while …

Abstract Chemical Exchange Saturation Transfer (CEST) MRI is sensitive to dilute
metabolites with exchangeable protons, allowing tissue characterization in diseases such as …

The ability to identify key biomolecules and molecular changes associated with cancer
malignancy and the capacity to monitor the therapeutic outcome against these targets is …

Purpose Chemical exchange saturation transfer (CEST) MRI is promising for detecting dilute
metabolites and microenvironment properties, which has been increasingly adopted in …

Cancer cell migration is a plastic and adaptive process integrating cytoskeletal dynamics,
cell–extracellular matrix and cell–cell adhesion, as well as tissue remodeling. In response to …