Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem
S Ghazisaeidi, MM Muley… - Annual Review of …, 2023 - annualreviews.org
The study of chronic pain continues to generate ever-increasing numbers of publications,
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
but safe and efficacious treatments for chronic pain remain elusive. Recognition of sex …
Sex and gender differences in pain
NR Osborne, KD Davis - International Review of Neurobiology, 2022 - Elsevier
Chronic pain affects 20% of adults and is one of the leading causes of disability worldwide.
Women and girls are disproportionally affected by chronic pain. About half of chronic pain …
Women and girls are disproportionally affected by chronic pain. About half of chronic pain …
Specialized pro-resolving mediators as resolution pharmacology for the control of pain and itch
RR Ji - Annual review of pharmacology and toxicology, 2023 - annualreviews.org
Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins,
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …
are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty …
Multifunctional DNA hydrogel enhances stemness of adipose‐derived stem cells to activate immune pathways for guidance burn wound regeneration
L Zhou, Z Zeng, S Liu, T Min, W Zhang… - Advanced Functional …, 2022 - Wiley Online Library
A grade 3 burn is a nonstatic fatal injury, which can lead to complete damage to the skin
structure, accompanied by a series of symptoms such as persistent inflammation, pain …
structure, accompanied by a series of symptoms such as persistent inflammation, pain …
Persistent nociceptor hyperactivity as a painful evolutionary adaptation
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized …
[HTML][HTML] Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25–Nrf2 pathway
Cross-talk between peripheral neurons and immune cells is important in pain sensation. We
identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain …
identified Snx25 as a pain-modulating gene in a transgenic mouse line with reduced pain …
Peripheral voltage-gated cation channels in neuropathic pain and their potential as therapeutic targets
SRA Alles, PA Smith - Frontiers in Pain Research, 2021 - frontiersin.org
The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …
neurons is imperative for the development and persistence of many forms of neuropathic …
A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models
C Paige, I Plasencia-Fernandez, M Kume… - Journal of …, 2022 - Soc Neuroscience
We aimed to investigate a sexually dimorphic role of calcitonin gene-related peptide (CGRP)
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
in rodent models of pain. Based on findings in migraine where CGRP has a preferential pain …
Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
However, when paclitaxel is used to treat tumors, patients commonly experience severe …