A how-to guide for mode of action analysis of antimicrobial peptides
AB Schäfer, M Wenzel - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a promising alternative to classical antibiotics in the fight
against multi-resistant bacteria. They are produced by organisms from all domains of life and …
against multi-resistant bacteria. They are produced by organisms from all domains of life and …
A staphylococcal capsule-producing enzyme that unfolds via multiple intermediates predominantly exists as the trimers at low concentrations
T Chakraborty, S Polley, N Ray Chaudhuri… - Journal of …, 2024 - Taylor & Francis
CapG, an enzyme expressed by Staphylococcus aureus, catalyzes an epimerization
reaction to synthesize N-acetyl-L-fucosamine, a constituent of capsule involved in …
reaction to synthesize N-acetyl-L-fucosamine, a constituent of capsule involved in …
The cofactors and domains of a staphylococcal capsule-producing enzyme preserve its structure, stability, shape and dimerization ability
CapF, a staphylococcal capsule-producing enzyme, binds Zn2+ ion and NADPH using its C-
terminal domain (CTD) and N-terminal domain (NTD), respectively. To elucidate the roles of …
terminal domain (CTD) and N-terminal domain (NTD), respectively. To elucidate the roles of …
Antibacterial discovery: problems and possibilities
LL Silver - Antibiotics: targets, mechanisms and resistance, 2013 - Wiley Online Library
The approach of selecting single enzymes as candidates for inhibition and development into
antibacterial agents has not proved as successful as hoped, and actually has been rather a …
antibacterial agents has not proved as successful as hoped, and actually has been rather a …