MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

Mechanisms of long noncoding RNA function in development and disease

SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …

Enhancers as non-coding RNA transcription units: recent insights and future perspectives

W Li, D Notani, MG Rosenfeld - Nature Reviews Genetics, 2016 - nature.com
Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

W Poller, S Dimmeler, S Heymans, T Zeller… - European heart …, 2018 - academic.oup.com
Recent research has demonstrated that the non-coding genome plays a key role in genetic
programming and gene regulation during development as well as in health and …

Long noncoding RNAs in cardiovascular diseases

S Uchida, S Dimmeler - Circulation research, 2015 - Am Heart Assoc
In recent year, increasing evidence suggests that noncoding RNAs play important roles in
the regulation of tissue homeostasis and pathophysiological conditions. Besides small …

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

R Micheletti, I Plaisance, BJ Abraham, A Sarre… - Science translational …, 2017 - science.org
Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of cardiac
development and disease. However, our understanding of the importance of these …

Long noncoding RNAs in kidney and cardiovascular diseases

JM Lorenzen, T Thum - Nature Reviews Nephrology, 2016 - nature.com
Transcription of a large part of the human genome results in RNA transcripts that have
limited or no protein-coding potential. These include long noncoding RNAs (lncRNAs) …

Long noncoding RNAs in cardiac development and ageing

Nature Reviews Cardiology, 2015 - nature.com
A large part of the mammalian genome is transcribed into noncoding RNAs. Long
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …

Long noncoding RNAs in cardiovascular pathology, diagnosis, and therapy

C Bär, S Chatterjee, T Thum - Circulation, 2016 - Am Heart Assoc
Vast parts of mammalian genomes encode for transcripts that are not further translated into
proteins. The purpose of the majority of such noncoding ribonucleic acids (RNAs) remained …

[HTML][HTML] CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis

S Ounzain, R Micheletti, C Arnan, I Plaisance… - Journal of molecular and …, 2015 - Elsevier
Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental
pathways. However, their roles in human cardiac precursor cell (CPC) remain unexplored …