Oleanolic acid: extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes

JM Castellano, A Guinda, T Delgado, M Rada… - Diabetes, 2013 - Am Diabetes Assoc
Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is
endowed with a wide range of pharmacological properties whose therapeutic potential has …

Oleanolic, ursolic, and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes: promise or illusion?

FSG Silva, PJ Oliveira, MF Duarte - Journal of agricultural and …, 2016 - ACS Publications
Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …

Inhibition of tumor progression by naturally occurring terpenoids

G Kuttan, P Pratheeshkumar, KA Manu… - Pharmaceutical …, 2011 - Taylor & Francis
Context: Cancer is a major public health problem in India and many other parts of the world.
Its two main characteristics are uncontrolled cell growth and metastasis. Natural products …

Therapeutic potentials of microalgae and their bioactive compounds on diabetes mellitus

K Tamel Selvan, JA Goon, S Makpol, JK Tan - Marine Drugs, 2023 - mdpi.com
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to impaired
insulin secretion, insulin resistance, or both. Oxidative stress and chronic low-grade …

Oleanolic acid and related triterpenoids from olives on vascular function: Molecular mechanisms and therapeutic perspectives

R Rodriguez-Rodriguez - Current medicinal chemistry, 2015 - ingentaconnect.com
Oleanolic acid and related triterpenoids from olives modulate different signaling pathways,
showing a wide range of pharmacological activities against inflammation, cancer or …

Human serum albumin (HSA) and its applications as a drug delivery vehicle

S Wang, S Liu, Y Zhang, J He, DH Coy… - Health Science …, 2020 - search.proquest.com
certain strategies have been applied to link the non-specific small molecular drugs to unique
drug delivery vehicles such as monoclonal antibodies, peptides and proteins [2].[...] HSA …

Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following islet transplantation

A Golocheikine, V Tiriveedhi, N Angaswamy… - …, 2010 - journals.lww.com
Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

Oleanolic acid reduces hyperglycemia beyond treatment period with Akt/FoxO1-induced suppression of hepatic gluconeogenesis in type-2 diabetic mice

XY Zeng, YP Wang, J Cantley, TJ Iseli, JC Molero… - 2012 - journals.plos.org
The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid
selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J …

Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORγt …

SH Kim, J Hong, YC Lee - International immunopharmacology, 2014 - Elsevier
The natural product oleanolic acid is commonly found in a variety of medicinal plants. It is a
triterpenoid compound known for its anti-inflammatory effects as well as various other …