Abstract Purpose of Review Effective acute pain management has evolved considerably in
recent years and is a primary area of focus in attempts to defend against the opioid …

Dexamethasone (DEX) has been widely used to treat a variety of diseases, including
autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19 …

Insufficient drug loading and leakage of payload remain major challenges in designing
liposome-based drug delivery systems. These phenomena can limit duration of effect and …

In cutaneous cosmetology surgery, local injection or coated anesthetics are generally used
to provide analgesia at the treatment site to achieve painless operation. Due to the barrier of …

Peripheral nerve block technology is important to balanced anesthesia technology. It can
effectively reduce opioid usage. It is the key to enhance clinical rehabilitation as an …

The remarkable number of new molecular entities approved per year as parenteral drugs,
such as biologics and complex active pharmaceutical ingredients, calls for innovative and …

Background and objectives Perineural dexamethasone or dexmedetomidine prolongs the
duration of single-injection peripheral nerve block when added to the local anesthetic …

An on-demand anesthetic that would only take effect when needed and where the intensity
of anesthesia could be easily adjustable according to patients' needs would be highly …

Background. Brachial plexus block is frequently recommended for upper limb surgeries.
Many drugs have been used as adjuvants to prolong the duration of the block. This study …

Efficient encapsulation and sustained release of small hydrophilic molecules from traditional
hydrogel systems are challenging due to the large mesh size of 3D networks and high water …