Prostate cancer is a global health problem, but incidence varies considerably across
different continents. Asia is traditionally considered a low-incidence area, but the incidence …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Treatments that target immune checkpoints, such as the one mediated by programmed cell
death protein 1 (PD-1) and its ligand PD-L1, have been approved for treating human …

Cancer is one of the greatest threats facing our society, being the second leading cause of
death globally. Currents strategies for cancer diagnosis consist of the extraction of a solid …

Background The prostate-specific antigen (PSA) test is used to screen for prostate cancer
but has a high false-positive rate that translates into unnecessary prostate biopsies and …

Introduction Many genetic variants associated with common disease susceptibility occur
close to immune-related genes in noncoding DNA, suggestive of a regulatory function. The …

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To
identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a …

Detection of circulating tumor DNAs (ctDNAs) in cancer patients is an important component
of cancer precision medicine ctDNAs. Compared to the traditional physical and biochemical …

Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

The incidence of prostate cancer (PCa) within Asian population used to be much lower than
in the Western population; however, in recent years the incidence and mortality rate of PCa …