Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing
serious nosocomial infections, which is considered as the most threatening Gram-negative …

The history of modern medicine cannot be written apart from the history of the antibiotics.
Antibiotics are cytotoxic secondary metabolites that are isolated from Nature. The …

Understanding how bactericidal antibiotics kill bacteria remains an open question. Previous
work has proposed that primary drug-target corruption leads to increased energetic …

Bacterial cell wall peptidoglycan is essential, maintaining both cellular integrity and
morphology, in the face of internal turgor pressure. Peptidoglycan synthesis is important, as …

The acquisition of resistance to one antibiotic sometimes leads to collateral sensitivity to a
second antibiotic. Here, we show that vancomycin resistance in Enterococcus faecium is …

The vast majority of genomic sequences are automatically annotated using various software
programs. The accuracy of these annotations depends heavily on the very few manual …

Summary β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the
bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It …

Acinetobacter baumannii is a strictly aerobic, nonmotile, nonfermenting, gram-negative
bacillus. It is a highly infectious and invasive pathogen with high mortality and morbidity …

The cell wall is a surface layer located outside the cell membrane of almost all bacteria; it
protects cells from environmental stresses and gives them their typical shape. The cell wall …

A recent genome-wide screen identified~ 300 essential or growth-supporting genes in the
dental caries pathogen Streptococcus mutans. To be able to study these genes, we built a …