Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi,
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …

Abstract Human Immunodeficiency Virus Type 1 (HIV-1) causes a chronic, incurable
infection associated with chronic inflammation despite virologic suppression on antiretroviral …

Astrocytes provide metabolic support for neurons and modulate their functions by releasing
a plethora of neuroactive molecules diffusing to neighboring cells. Here we report that …

Human Immunodeficiency Virus Type 1 (HIV-1) presents significant challenges to the
immune system, predominantly characterized by CD4+ T cell depletion, leading to Acquired …

Human immunodeficiency virus type 1 (HIV-1) causes a chronic infection that afflicts more
than 30 million individuals worldwide. While the infection can be suppressed with potent …

Purinergic receptors are inflammatory mediators activated by extracellular nucleotides
released by dying or injured cells. Several studies have described an important role for …

G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of
mammalian transmembrane proteins. These receptors are involved in a wide range of …

Identifying signaling pathways and molecules involved in SARS-CoV-2 pathogenesis is
pivotal for developing new effective therapeutic or preventive strategies for COVID-19 …