Pathogenesis of Genital Tract Disease Due to Chlamydia trachomatis

T Darville, TJ Hiltke - The Journal of infectious diseases, 2010 - academic.oup.com
Although the pathologic consequences of C. trachomatis genital infection are well-
established, themechanism (s) that result in chlamydia-induced tissue damage are not fully …

Immunity to murine chlamydial genital infection

RP Morrison, HD Caldwell - Infection and immunity, 2002 - Am Soc Microbiol
Chlamydia trachomatis sexually transmitted infections cause considerable morbidity and
socioeconomic burden worldwide, despite significant advances in our understanding of the …

Hidden in plain sight: chlamydial gastrointestinal infection and its relevance to persistence in human genital infection

RG Rank, L Yeruva - Infection and immunity, 2014 - Am Soc Microbiol
Although the concept of persistence in chlamydial infections has been recognized for about
80 years, there is still very little known about the mechanism by which this occurs. In this …

Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection

T Darville, JM O'Neill, CW Andrews… - The Journal of …, 2003 - journals.aai.org
The roles of Toll-like receptor (TLR) 2 and TLR4 in the host inflammatory response to
infection caused by Chlamydia trachomatis have not been elucidated. We examined …

Immunity to Murine Chlamydia trachomatis Genital Tract Reinfection Involves B Cells and CD4+ T Cells but Not CD8+ T Cells

SG Morrison, H Su, HD Caldwell… - Infection and …, 2000 - Am Soc Microbiol
ABSTRACT CD4+ T-helper type 1 (Th1) responses are essential for the resolution of a
primary Chlamydia trachomatis genital tract infection; however, elements of the immune …

Chlamydia and Chlamydiales: more than meets the eye

KDE Everett - Veterinary microbiology, 2000 - Elsevier
This review summarizes the dramatic changes that have occurred in the taxonomy of
bacteria known as Chlamydia. Best known for the diseases they cause in humans, these …

Update on Chlamydia trachomatis vaccinology

LM de la Maza, G Zhong… - Clinical and Vaccine …, 2017 - Am Soc Microbiol
Attempts to produce a vaccine to protect against Chlamydia trachomatis-induced trachoma
were initiated more than 100 years ago and continued for several decades. Using whole …

A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection

SG Morrison, RP Morrison - The Journal of immunology, 2005 - journals.aai.org
Acquired immunity to murine Chlamydia trachomatis genital tract reinfection has long been
assumed to be solely dependent on cell-mediated immunity. However, in this study, we …

The role of IFN-γ in the outcome of chlamydial infection

ME Rottenberg, A Gigliotti-Rothfuchs… - Current opinion in …, 2002 - Elsevier
Chlamydia are intracellular bacteria which infect many vertebrates, including humans. They
cause a myriad of severe diseases, ranging from asymptomatic infection to pneumonia …

The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword

KA Redgrove, EA McLaughlin - Frontiers in immunology, 2014 - frontiersin.org
Chlamydia trachomatis (CT) is the most prevalent bacterial sexually transmitted infection in
the world, with more than 100 million cases reported annually. While there have been …