Colistin regained global interest as a consequence of the rising prevalence of multidrug-
resistant Gram-negative Enterobacteriaceae. In parallel, colistin-resistant bacteria emerged …

Antibiotic resistance has become a global public health priority. Polymyxins, a family of
cationic polypeptide antibiotics, act as a final line of refuge against severe infections by …

Abstract The Working Party makes more than 100 tabulated recommendations in
antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) …

Objectives To determine the occurrence of mcr-1 and mcr-2 genes in Gram-negative
bacteria isolated from healthy pigs in Great Britain. Methods Gram-negative bacteria (n …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Antimicrobial resistance (AMR) is a global health problem. Bacteria carrying resistance
genes can be transmitted between humans, animals and the environment. There are …

Background: Antimicrobial resistance is a serious public-health problem throughout the
world. Escherichia coli, the most common Gram-negative microorganism, has developed …

Colistin, also known as polymyxin E, is an antimicrobial agent that is effective against a
variety of Gram-negative bacilli, especially the Enterobacteriaceae family. Recently, the wide …

Molecular characterization of the genetic mechanism (s) underlying a given phenotypic
result, obtained by traditional antimicrobial sensitivity testing, is now an integral part of many …

The intersection of human, animal, and ecosystem health at One Health interfaces is
recognised as being of key importance in the evolution and spread of antimicrobial …