Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

Neuropathology of incidental Lewy body & prodromal Parkinson's disease

T Koeglsperger, SL Rumpf, P Schließer… - Molecular …, 2023 - Springer
Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

Proteostasis failure in neurodegenerative diseases: focus on oxidative stress

A Höhn, A Tramutola, R Cascella - Oxidative medicine and …, 2020 - Wiley Online Library
Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

Translational molecular imaging and drug development in Parkinson's disease

A Haider, NH Elghazawy, A Dawoud… - Molecular …, 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects
elderly people and constitutes a major source of disability worldwide. Notably, the …

Systematic review on Parkinson's disease medications, emphasizing on three recently approved drugs to control Parkinson's symptoms

P Sivanandy, TC Leey, TC Xiang, TC Ling… - International journal of …, 2021 - mdpi.com
Parkinson's Disease (PD) is a disease that involves neurodegeneration and is characterised
by the motor symptoms which include muscle rigidity, tremor, and bradykinesia. Other non …

Interactions between the microbiota and enteric nervous system during gut-brain disorders

S Fried, E Wemelle, PD Cani, C Knauf - Neuropharmacology, 2021 - Elsevier
For the last 20 years, researchers have focused their intention on the impact of gut
microbiota in healthy and pathological conditions. This year (2021), more than 25,000 …

The influence of pathogenic mutations in α-synuclein on biophysical and structural characteristics of amyloid fibrils

FS Ruggeri, P Flagmeier, JR Kumita, G Meisl… - ACS …, 2020 - ACS Publications
Proteinaceous deposits of α-synuclein amyloid fibrils are a hallmark of human disorders
including Parkinson's disease. The onset of this disease is also associated with five familial …

Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases

G Forloni, V Artuso, P La Vitola… - Movement …, 2016 - Wiley Online Library
The term oligomeropathies defines the neurodegenerative disorders associated with protein
misfolding, where small soluble aggregates (oligomers 4‐200 KDa) are the cause of …

The cell biology of tau secretion

M Merezhko, RL Uronen, HJ Huttunen - Frontiers in Molecular …, 2020 - frontiersin.org
The progressive accumulation and spread of misfolded tau protein in the nervous system is
the hallmark of tauopathies, progressive neurodegenerative diseases with only symptomatic …

An assessment of the rescue action of resveratrol in parkin loss of function-induced oxidative stress in Drosophila melanogaster

AO Adedara, AD Babalola, F Stephano… - Scientific Reports, 2022 - nature.com
Loss-of-function mutations in parkin is associated with onset of juvenile Parkinson's disease
(PD). Resveratrol is a polyphenolic stilbene with neuroprotective activity. Here, we evaluated …