Acute graft-versus-host disease

F Malard, E Holler, BM Sandmaier, H Huang… - Nature Reviews …, 2023 - nature.com
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

[HTML][HTML] Supporting information retrieval from electronic health records: a report of University of Michigan's nine-year experience in developing and using the …

DA Hanauer, Q Mei, J Law, R Khanna… - Journal of biomedical …, 2015 - Elsevier
Objective This paper describes the University of Michigan's nine-year experience in
developing and using a full-text search engine designed to facilitate information retrieval (IR) …

Pathophysiology of GvHD and other HSCT-related major complications

S Ghimire, D Weber, E Mavin, XN Wang… - Frontiers in …, 2017 - frontiersin.org
For over 60 years, hematopoietic stem cell transplantation has been the major curative
therapy for several hematological and genetic disorders, but its efficacy is limited by the …

[HTML][HTML] An early-biomarker algorithm predicts lethal graft-versus-host disease and survival

MJ Hartwell, U Özbek, E Holler, AS Renteria… - JCI insight, 2017 - ncbi.nlm.nih.gov
BACKGROUND. No laboratory test can predict the risk of nonrelapse mortality (NRM) or
severe graft-versus-host disease (GVHD) after hematopoietic cellular transplantation (HCT) …

ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death

MT Vander Lugt, TM Braun, S Hanash… - … England Journal of …, 2013 - Mass Medical Soc
Background No plasma biomarkers are associated with the response of acute graft-versus-
host disease (GVHD) to therapy after allogeneic hematopoietic stem-cell transplantation …

Tumor necrosis factor α and regulatory T cells in oncoimmunology

BL Salomon, M Leclerc, J Tosello, E Ronin… - Frontiers in …, 2018 - frontiersin.org
Tumor necrosis factor α (TNF) is a potent pro-inflammatory cytokine that has deleterious
effect in some autoimmune diseases, which led to the use of anti-TNF drugs in some of …

MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD

H Major-Monfried, AS Renteria… - Blood, The Journal …, 2018 - ashpublications.org
Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid
immunosuppression. Clinical response after 1 week of therapy often guides further treatment …

A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study

JE Levine, TM Braun, AC Harris, E Holler… - The Lancet …, 2015 - thelancet.com
Background Graft-versus-host disease (GVHD) is the major cause of non-relapse mortality
after allogeneic haemopoietic stem-cell transplantation (SCT). The severity of symptoms at …

Mouse models of graft-versus-host disease: advances and limitations

MA Schroeder, JF DiPersio - Disease models & …, 2011 - journals.biologists.com
The limiting factor for successful hematopoietic stem cell transplantation (HSCT) is graft-
versus-host disease (GvHD), a post-transplant disorder that results from immune-mediated …