The biomedical use of silk: past, present, future

C Holland, K Numata… - Advanced healthcare …, 2019 - Wiley Online Library
Humans have long appreciated silk for its lustrous appeal and remarkable physical
properties, yet as the mysteries of silk are unraveled, it becomes clear that this outstanding …

Complexity of spider dragline silk

AD Malay, HC Craig, J Chen, NA Oktaviani… - …, 2022 - ACS Publications
The tiny spider makes dragline silk fibers with unbeatable toughness, all under the most
innocuous conditions. Scientists have persistently tried to emulate its natural silk spinning …

Spider silk self-assembly via modular liquid-liquid phase separation and nanofibrillation

AD Malay, T Suzuki, T Katashima, N Kono… - Science …, 2020 - science.org
Spider silk fiber rapidly assembles from spidroin protein in soluble state via an incompletely
understood mechanism. Here, we present an integrated model for silk formation that …

Metal ions guide the production of silkworm silk fibers

O Brookstein, E Shimoni, D Eliaz… - Nature …, 2024 - nature.com
Silk fibers' unique mechanical properties have made them desirable materials, yet their
formation mechanism remains poorly understood. While ions are known to support silk fiber …

Interplay of different major ampullate spidroins during assembly and implications for fiber mechanics

M Saric, L Eisoldt, V Döring, T Scheibel - Advanced Materials, 2021 - Wiley Online Library
Major ampullate (MA) spider silk has fascinating mechanical properties combining strength
and elasticity. All known natural MA silks contain at least two or more different spidroins; …

Tensan silk-inspired hierarchical fibers for smart textile applications

W Zhang, C Ye, K Zheng, J Zhong, Y Tang, Y Fan… - ACS …, 2018 - ACS Publications
Tensan silk, a natural fiber produced by the Japanese oak silk moth (Antherea yamamai,
abbreviated to A. yamamai), features superior characteristics, such as compressive elasticity …

Liquid-liquid crystalline phase separation of spider silk proteins

M Landreh, H Osterholz, G Chen, SD Knight… - Communications …, 2024 - nature.com
Liquid-liquid phase separation (LLPS) of proteins can be considered an intermediate
solubility regime between disperse solutions and solid fibers. While LLPS has been …

Sustainable spinning of artificial spider silk fibers with excellent toughness and inherent potential for functionalization

R Fan, K Knuuttila, B Schmuck, G Greco… - Advanced Functional …, 2024 - Wiley Online Library
Despite impressive progress in the field, there are still several major bottlenecks in
producing fibers from recombinantly produced spider‐silk‐like proteins to replicate the …

On the origin of supercontraction in spider silk

N Cohen, M Levin, CD Eisenbach - Biomacromolecules, 2021 - ACS Publications
Spider silk is a protein material that exhibits extraordinary and nontrivial properties such as
the ability to soften and decrease its length by up to∼ 60% upon exposure to high humidity …

Liquid–liquid phase separation and assembly of silk-like proteins is dependent on the polymer length

L Lemetti, A Scacchi, Y Yin, M Shen, MB Linder… - …, 2022 - ACS Publications
Phase transitions have an essential role in the assembly of nature's protein-based materials
into hierarchically organized structures, yet many of the underlying mechanisms and …