The construction of carbon− carbon bonds, along with the creation of stereogenic carbon
centers, continues to be an appealing and demanding area of research, and processes in …

Sequential reactions, through the incorporation of several distinct transformations into one
single sequence, are one of the most powerful synthetic tools in modern organic chemistry …

Since about the year 2000, the research area of asymmetric organocatalysis has grown
rapidly to become one of the most fascinating and current fields in organic chemistry. In the …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

The α-ketoamide motif is widely found in many natural products and drug candidates with
relevant biological activities. Furthermore, α-ketoamides are attractive candidates to …

Controllable production of α‐keto amides and amides from the same substrates is an
attractive goal in the field of transition‐metal‐catalyzed (double‐) carbonylation. Herein, a …

Beyond a doubt organocatalysis belongs to the most exciting and innovative chapters of
organic chemistry today. Organocatalysis has emerged not only as a complement to metal …

In-depth understanding of the activation mechanism in asymmetric organocatalysis is of
great importance for rational development of highly efficient catalytic systems. In this Article …

Drug‐like spirocyclic scaffolds have been prepared asymmetrically by fusing fully
functionalized cyclohexanes with medicinally important pyrazolone, rhodanine, barbituric …

α-Ketoamides and their derivatives are key constituents of natural products, biologically
relevant molecules, drug and drug candidates, and functional materials. Further, they are …