Apicomplexan parasites constitute more than 6,000 species infecting a wide range of hosts.
These include important pathogens such as those causing malaria and toxoplasmosis. Their …

Human dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial
enzyme catalyzing the fourth step in the de novo pyrimidine synthesis pathway. It is …

The RAP (RNA-binding domain abundant in Apicomplexans) protein family has been
identified in various organisms. Despite expansion of this protein family in apicomplexan …

One of the most powerful approaches to understanding gene function involves turning
genes on and off at will and measuring the impact at the cellular or organismal level. This …

Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases that
mediate membrane dynamics or organellar fission/fusion events. Plasmodium falciparum …

Mitochondria are vital organelles of eukaryotic cells, participating in key metabolic pathways
such as cellular respiration, thermogenesis, maintenance of cellular redox potential, calcium …

The emergence of resistance to conventional antimalarial treatments remains a major cause
for concern. New drugs that target the distinct development stages of Plasmodium parasites …

The phylum Apicomplexa comprises eukaryotic parasites that cause fatal diseases affecting
millions of people and animals worldwide. Their mitochondrial genomes have been …

Apicomplexan parasites encompass diverse pathogens for humans and animals, including
the causative agents of malaria and toxoplasmosis, Plasmodium spp. and Toxoplasma …

Mitochondrial ribosomes (mitoribosomes) are essential, and their function of synthesising
mitochondrial proteins is universal. The core of almost all mitoribosomes is formed from a …