Sickle cell disease (SCD) substantially alters renal structure and function, and causes
various renal syndromes and diseases. Such diverse renal outcomes reflect the uniquely …

The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …

Sickle cell anemia (SCA) is a disease caused by production of abnormal hemoglobin, which
binds with other abnormal hemoglobin molecules within the red blood cell to cause rigid …

The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Patients with sickle cell anemia (SCA) may develop a glomerulopathy with proteinuria and
progressive renal insufficiency, leading to ESRD. Albuminuria is a sensitive marker of …

Screening for pulmonary hypertension (pHTN) has not yet become routine in sickle cell
disease (SCD), despite clinical evidence of its high prevalence and associated mortality. Our …

Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme
oxygenase-1. Background Heme oxygenase (HO) is the rate-limiting enzyme in the …

OBJECTIVES: To investigate the pathologic, clinical, and genetic features of renal medullary
carcinomas (RMCs) in search of clues to their pathogenesis. METHODS: We analyzed 40 …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Well organized and highly readable, the National Kidney Foundation Primer on Kidney
Diseases has offered clear, comprehensive coverage of adult and pediatric kidney diseases …