MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death

R Schickel, B Boyerinas, SM Park, ME Peter - Oncogene, 2008 - nature.com
Micro (mi) RNAs are small, highly conserved noncoding RNAs that control gene expression
post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein …

Roles of HMGA proteins in cancer

A Fusco, M Fedele - Nature Reviews Cancer, 2007 - nature.com
The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure
and thereby regulate the transcription of several genes by either enhancing or suppressing …

Retracted: LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR‐20a‐5p/HMGA2 axis in breast cancer

W Zhao, D Geng, S Li, Z Chen, M Sun - Cancer medicine, 2018 - Wiley Online Library
To study the regulatory effect of lnc RNA HOTAIR/miR‐20a‐5p/HMGA 2 axis on breast
cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of …

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis

M Sun, CX Song, H Huang… - Proceedings of the …, 2013 - National Acad Sciences
The ten–eleven translocation (TET) family of methylcytosine dioxygenases initiates
demethylation of DNA and is associated with tumorigenesis in many cancers; however, the …

Let-7 expression defines two differentiation stages of cancer

S Shell, SM Park, AR Radjabi… - Proceedings of the …, 2007 - National Acad Sciences
The early phases of carcinogenesis resemble embryonic development, often involving the
reexpression of embryonic mesenchymal genes. The NCI60 panel of human tumor cell lines …

MicroRNA let-7: an emerging next-generation cancer therapeutic

D Barh, R Malhotra, B Ravi, P Sindhurani - Current oncology, 2010 - pmc.ncbi.nlm.nih.gov
In recent years, various rna-based technologies have been under evaluation as potential
next-generation cancer therapeutics. Micrornas (mirnas), known to regulate the cell cycle …

The HMGA proteins: a myriad of functions

I Cleynen, WJM Van de Ven - … journal of oncology, 2008 - spandidos-publications.com
The 'high mobility group'HMGA protein family consists of four members: HMGA1a, HMGA1b
and HMGA1c, which result from translation of alternative spliced forms of one gene and …

Regulation of let-7 and its target oncogenes

X Wang, LEI Cao, Y Wang, X Wang… - Oncology …, 2012 - spandidos-publications.com
MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which
were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of …

[HTML][HTML] MicroRNAs: molecular features and role in cancer

E Lages, H Ipas, A Guttin, H Nesr, F Berger… - Frontiers in …, 2012 - ncbi.nlm.nih.gov
Abstract microRNAs (miRNAs) are small noncoding endogenously produced RNAs that play
key roles in controlling the expression of many cellular proteins. Once they are recruited and …

Clinical Significance of High Mobility Group A2 in Human Gastric Cancer and Its Relationship to let-7 MicroRNA Family

K Motoyama, H Inoue, Y Nakamura, H Uetake… - Clinical cancer …, 2008 - AACR
Purpose: The high mobility group A2 (HMGA2) nonhistone chromosomal protein can
modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during …