Propofol administered in conjunction with an opioid such as remifentanil is used to provide
total intravenous anesthesia for children. Drugs can be given as infusion controlled …

Pain management in the pediatric population is complex for many reasons. Mild pain is
usually managed quite well with oral acetaminophen or ibuprofen. Situations involving more …

We are witnessing a notable rise in the translational use of information technology and
control systems engineering tools in clinical practice. This paper empowers the computer …

Understanding the dose–concentration–effect relationship is a fundamental component of
clinical pharmacology. Interpreting data arising from observations of this relationship …

Fentanyl and its derivatives sufentanil, alfentanil, and remifentanil are potent opioids. A
comprehensive review of the use of fentanyl and its derivatives in the pediatric population …

Pharmacokinetic (PK) and pharmacodynamic (PD) modeling has elucidated aspects of
developmental pharmacology of value to the anesthetic community. The increasing …

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and
conduct of clinical pharmacology research in children. During drug development, PKPD …

Medication errors in pediatric anesthesia represent an important risk to children. Concerted
action to reduce harm from this cause is overdue. An understanding of the genesis of …

Background This randomized, double-blind study was designed to assess the effect of
perioperative remifentanil with controlled hypotension on intraoperative bleeding …

Background The management of procedural pain in children ranges from physical restraint
to pharmacological interventions. Pediatric formulations that permit accurate dosing, are …