Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

Conditional gene expression has greatly facilitated the examination of the functions of
particular gene products. Using the Cre/lox P switching expression system, we plan to …

Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into
peptides. There are many distinct forms of proteasomes that differ in catalytically active …

There is substantial need for molecularly defined tumor antigens to prime cytotoxic T cells in
vivo for cancer immunotherapy, especially in the case of tumor entities for which only a few …

Summary Interferon (IFN)-induced immunoproteasomes (i-proteasomes) have been
associated with improved processing of major histocompatibility complex (MHC) class I …

Constitutive proteasomes and immunoproteasomes shape the peptide repertoire presented
by major histocompatibility complex class I (MHC-I) molecules by harboring different sets of …

With the recent developments of adoptive T cell therapies and the use of new monoclonal
antibodies against the immune checkpoints, immunotherapy is at a turning point. Key …