Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

LC3-associated endocytosis (LANDO) is a noncanonical function of the autophagy
machinery, in which LC3 (microtubule-associated protein light chain) is conjugated to rab5 …

Non-canonical autophagy is a key cellular pathway in immunity, cancer, and
neurodegeneration, characterized by conjugation of ATG8 to endolysosomal single …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

In response to infection, macrophages adapt their metabolism rapidly to enhance glycolysis
and fuel specialized antimicrobial effector functions. Here we show that fungal melanin is an …

The delivery of pathogens to lysosomes for degradation provides an important defense
against infection. Degradation is enhanced when LC3 is conjugated to endosomes and …

Millions of hibernating bats across North America have died from white-nose syndrome
(WNS), an emerging disease caused by a psychrophilic (cold-loving) fungus …

Phagocytes ingest, kill and degrade invading microbes in a process called phagocytosis.
LC3-associated phagocytosis (LAP) combines the molecular machinery of phagocytosis …

The decision whether endosomes enter the degradative or recycling pathway in mammalian
cells is of fundamental importance for pathogen killing, and its malfunctioning has …

Melanins are ubiquitous complex polymers that are commonly known in humans to cause
pigmentation of our skin. Melanins are also present in bacteria, fungi, and helminths. In this …