The protease renin is the key enzyme of the renin-angiotensin-aldosterone cascade, which
is relevant under both physiological and pathophysiological settings. The kidney is the only …

Ischemia-induced acute renal failure (ARF) is a disorder with high morbidity and mortality.
ARF is characterized by a regeneration phase, yet its molecular basis is still under study …

Abstract Background/Aims: The role of COX-2 for renal function during renal development,
for physiology and pathophysiology of renal diseases and the side effects of available COX …

Boldine, a major aporphine alkaloid found in the Chilean boldo tree, is a potent antioxidant.
Oxidative stress plays a detrimental role in the pathogenesis of kidney damage in …

Background Megalin is a large endocytic receptor with relevant functions during
development and adult life. It is expressed at the apical surface of several epithelial cell …

Recovery from acute renal failure (ARF) requires the replacement of injured cells with new
cells that restore tubule epithelial integrity. We described recently the expression of a wide …

Stimulation of BK2R (bradykinin [BK] B2 receptor) has been shown to increase renal Na+
excretion. The aim of the present study is to explore the role of BK2R in regulating Kir4. 1 …

In various models of chronic kidney disease, the amount and localization of Cx43 in the
nephron is known to increase, but the intracellular pathways that regulate these changes …

Recovery from acute renal failure (ARF) requires the replacement of injured cells by new
cells that are able to restore tubule epithelial integrity. We have recently described the …

Chronic kidney disease (CKD) is characterized by loss of renal function. The pathological
processes involved in the progression of this condition are already known, but the molecular …